Towards Active Real-to-Twin Inspection: A New Paradigm for Zero-Shot Anomaly Detection

The deployment of zero-shot anomaly detection (AD) in embodied industrial inspection is severely bottlenecked by its reliance on passive, fixed-viewpoint 2D imagery. Such formulations inherently fail to accommodate the active, dynamic observations required in real-world environments. To break this limitation, we introduce Real-to-Twin Anomaly Detection, a novel task that evaluates physical observations directly against geometrically matched CAD Digital Twins. To tackle this new task, we propose AVATAR, a framework designed to learn robust semantic alignment between Real and Digital Twins. By bridging benign Sim2Real domain gaps using only defect-free pairs, AVATAR effectively transforms CAD priors into dynamic, anomaly-free references. This elegant formulation enables the model to localize diverse anomalies in a zero-shot manner as unalignable deviations, eliminating the need for defect annotations. Extensive experiments demonstrate that AVATAR substantially outperforms adapted state-of-the-art baselines, exhibiting exceptional robustness to severe viewpoint variations. The code and dataset will be made publicly available.

ConceptSeg-R1: Segment Any Concept via Meta-Reinforcement Learning

Recent progress in promptable segmentation has shifted visual perception from object-level localization toward concept-level understanding. However, the notion of a concept remains under-specified, making it unclear whether current methods truly generalize beyond category recognition. In this work, we formalize generalized concept segmentation through a three-level taxonomy consisting of context-independent (CI), context-dependent (CD), and context-reasoning (CR) concepts, which reveals a clear capability gap across increasing levels of cognitive complexity. To address this challenge, we propose ConceptSeg-R1, a unified framework that reformulates concept segmentation as rule-induced concept grounding. At the core of our method is Meta-GRPO, a meta-reinforcement learning mechanism that learns transferable task rules from visual demonstrations and verifies them through proxy reasoning. The inferred reasoning states are then translated into segmentation-ready concept prompts via a lightweight concept translation module, enabling deductive application to target images. A shortcut routing strategy further preserves the native efficiency of segmentation models on simple cases. To systematically evaluate generalized concept segmentation, we conduct extensive experiments across diverse CI, CD, and CR concept segmentation benchmarks spanning natural, industrial, medical and reasoning-intensive domains. Without bells and whistles, ConceptSeg-R1 achieves strong performance across the full concept hierarchy while maintaining the native capability of promptable segmentation backbones. As an initial step toward segmenting any concept, we hope ConceptSeg-R1 can serve as a practical baseline for advancing segmentation from object-level prediction toward concept-level understanding.

Synthesis4AD: Synthetic Anomalies are All You Need for 3D Anomaly Detection

Industrial 3D anomaly detection performance is fundamentally constrained by the scarcity and long-tailed distribution of abnormal samples. To address this challenge, we propose Synthesis4AD, an end-to-end paradigm that leverages large-scale, high-fidelity synthetic anomalies to learn more discriminative representations for 3D anomaly detection. At the core of Synthesis4AD is 3D-DefectStudio, a software platform built upon the controllable synthesis engine MPAS, which injects geometrically realistic defects guided by higher-dimensional support primitives while simultaneously generating accurate point-wise anomaly masks. Furthermore, Synthesis4AD incorporates a multimodal large language model (MLLM) to interpret product design information and automatically translate it into executable anomaly synthesis instructions, enabling scalable and knowledge-driven anomalous data generation. To improve the robustness and generalization of the downstream detector on unstructured point clouds, Synthesis4AD further introduces a training pipeline based on spatial-distribution normalization and geometry-faithful data augmentations, which alleviates the sensitivity of Point Transformer architectures to absolute coordinates and improves feature learning under realistic data variations. Extensive experiments demonstrate state-of-the-art performance on Real3D-AD, MulSen-AD, and a real-world industrial parts dataset. The proposed synthesis method MPAS and the interactive system 3D-DefectStudio will be publicly released at https://github.com/hustCYQ/Synthesis4AD.

URA-Net: Uncertainty-Integrated Anomaly Perception and Restoration Attention Network for Unsupervised Anomaly Detection

Unsupervised anomaly detection plays a pivotal role in industrial defect inspection and medical image analysis, with most methods relying on the reconstruction framework. However, these methods may suffer from over-generalization, enabling them to reconstruct anomalies well, which leads to poor detection performance. To address this issue, instead of focusing solely on normality reconstruction, we propose an innovative Uncertainty-Integrated Anomaly Perception and Restoration Attention Network (URA-Net), which explicitly restores abnormal patterns to their corresponding normality. First, unlike traditional image reconstruction methods, we utilize a pre-trained convolutional neural network to extract multi-level semantic features as the reconstruction target. To assist the URA-Net learning to restore anomalies, we introduce a novel feature-level artificial anomaly synthesis module to generate anomalous samples for training. Subsequently, a novel uncertainty-integrated anomaly perception module based on Bayesian neural networks is introduced to learn the distributions of anomalous and normal features. This facilitates the estimation of anomalous regions and ambiguous boundaries, laying the foundation for subsequent anomaly restoration. Then, we propose a novel restoration attention mechanism that leverages global normal semantic information to restore detected anomalous regions, thereby obtaining defect-free restored features. Finally, we employ residual maps between input features and restored features for anomaly detection and localization. The comprehensive experimental results on two industrial datasets, MVTec AD and BTAD, along with a medical image dataset, OCT-2017, unequivocally demonstrate the effectiveness and superiority of the proposed method.

Reason-IAD: Knowledge-Guided Dynamic Latent Reasoning for Explainable Industrial Anomaly Detection

Industrial anomaly detection demands precise reasoning over fine-grained defect patterns. However, existing multimodal large language models (MLLMs), pretrained on general-domain data, often struggle to capture category-specific anomalies, thereby limiting both detection accuracy and interpretability. To address these limitations, we propose Reason-IAD, a knowledge-guided dynamic latent reasoning framework for explainable industrial anomaly detection. Reason-IAD comprises two core components. First, a retrieval-augmented knowledge module incorporates category-specific textual descriptions into the model input, enabling context-aware reasoning over domain-specific defects. Second, an entropy-driven latent reasoning mechanism conducts iterative exploration within a compact latent space using optimizable latent think tokens, guided by an entropy-based reward that encourages confident and stable predictions. Furthermore, a dynamic visual injection strategy selectively incorporates the most informative image patches into the latent sequence, directing the reasoning process toward regions critical for anomaly detection. Extensive experimental results demonstrate that Reason-IAD consistently outperforms state-of-the-art methods. The code will be publicly available at https://github.com/chenpeng052/Reason-IAD.

Rethinking Genomic Modeling Through Optical Character Recognition

Recent genomic foundation models largely adopt large language model architectures that treat DNA as a one-dimensional token sequence. However, exhaustive sequential reading is structurally misaligned with sparse and discontinuous genomic semantics, leading to wasted computation on low-information background and preventing understanding-driven compression for long contexts. Here, we present OpticalDNA, a vision-based framework that reframes genomic modeling as Optical Character Recognition (OCR)-style document understanding. OpticalDNA renders DNA into structured visual layouts and trains an OCR-capable vision--language model with a \emph{visual DNA encoder} and a \emph{document decoder}, where the encoder produces compact, reconstructible visual tokens for high-fidelity compression. Building on this representation, OpticalDNA defines prompt-conditioned objectives over core genomic primitives-reading, region grounding, subsequence retrieval, and masked span completion-thereby learning layout-aware DNA representations that retain fine-grained genomic information under a reduced effective token budget. Across diverse genomic benchmarks, OpticalDNA consistently outperforms recent baselines; on sequences up to 450k bases, it achieves the best overall performance with nearly $20\times$ fewer effective tokens, and surpasses models with up to $985\times$ more activated parameters while tuning only 256k \emph{trainable} parameters.

VTFusion: A Vision-Text Multimodal Fusion Network for Few-Shot Anomaly Detection

Few-Shot Anomaly Detection (FSAD) has emerged as a critical paradigm for identifying irregularities using scarce normal references. While recent methods have integrated textual semantics to complement visual data, they predominantly rely on features pre-trained on natural scenes, thereby neglecting the granular, domain-specific semantics essential for industrial inspection. Furthermore, prevalent fusion strategies often resort to superficial concatenation, failing to address the inherent semantic misalignment between visual and textual modalities, which compromises robustness against cross-modal interference. To bridge these gaps, this study proposes VTFusion, a vision-text multimodal fusion framework tailored for FSAD. The framework rests on two core designs. First, adaptive feature extractors for both image and text modalities are introduced to learn task-specific representations, bridging the domain gap between pre-trained models and industrial data; this is further augmented by generating diverse synthetic anomalies to enhance feature discriminability. Second, a dedicated multimodal prediction fusion module is developed, comprising a fusion block that facilitates rich cross-modal information exchange and a segmentation network that generates refined pixel-level anomaly maps under multimodal guidance. VTFusion significantly advances FSAD performance, achieving image-level AUROCs of 96.8% and 86.2% in the 2-shot scenario on the MVTec AD and VisA datasets, respectively. Furthermore, VTFusion achieves an AUPRO of 93.5% on a real-world dataset of industrial automotive plastic parts introduced in this paper, further demonstrating its practical applicability in demanding industrial scenarios.

AnyAD: Unified Any-Modality Anomaly Detection in Incomplete Multi-Sequence MRI

Reliable anomaly detection in brain MRI remains challenging due to the scarcity of annotated abnormal cases and the frequent absence of key imaging modalities in real clinical workflows. Existing single-class or multi-class anomaly detection (AD) models typically rely on fixed modality configurations, require repetitive training, or fail to generalize to unseen modality combinations, limiting their clinical scalability. In this work, we present a unified Any-Modality AD framework that performs robust anomaly detection and localization under arbitrary MRI modality availability. The framework integrates a dual-pathway DINOv2 encoder with a feature distribution alignment mechanism that statistically aligns incomplete-modality features with full-modality representations, enabling stable inference even with severe modality dropout. To further enhance semantic consistency, we introduce an Intrinsic Normal Prototypes (INPs) extractor and an INP-guided decoder that reconstruct only normal anatomical patterns while naturally amplifying abnormal deviations. Through randomized modality masking and indirect feature completion during training, the model learns to adapt to all modality configurations without re-training. Extensive experiments on BraTS2018, MU-Glioma-Post, and Pretreat-MetsToBrain-Masks demonstrate that our approach consistently surpasses state-of-the-art industrial and medical AD baselines across 7 modality combinations, achieving superior generalization. This study establishes a scalable paradigm for multimodal medical AD under real-world, imperfect modality conditions. Our source code is available at https://github.com/wuchangw/AnyAD.

Prototypical Learning Guided Context-Aware Segmentation Network for Few-Shot Anomaly Detection

Few-shot anomaly detection (FSAD) denotes the identification of anomalies within a target category with a limited number of normal samples. Existing FSAD methods largely rely on pre-trained feature representations to detect anomalies, but the inherent domain gap between pre-trained representations and target FSAD scenarios is often overlooked. This study proposes a Prototypical Learning Guided Context-Aware Segmentation Network (PCSNet) to address the domain gap, thereby improving feature descriptiveness in target scenarios and enhancing FSAD performance. In particular, PCSNet comprises a prototypical feature adaption (PFA) sub-network and a context-aware segmentation (CAS) sub-network. PFA extracts prototypical features as guidance to ensure better feature compactness for normal data while distinct separation from anomalies. A pixel-level disparity classification loss is also designed to make subtle anomalies more distinguishable. Then a CAS sub-network is introduced for pixel-level anomaly localization, where pseudo anomalies are exploited to facilitate the training process. Experimental results on MVTec and MPDD demonstrate the superior FSAD performance of PCSNet, with 94.9% and 80.2% image-level AUROC in an 8-shot scenario, respectively. Real-world applications on automotive plastic part inspection further demonstrate that PCSNet can achieve promising results with limited training samples. Code is available at https://github.com/yuxin-jiang/PCSNet.

Anomagic: Crossmodal Prompt-driven Zero-shot Anomaly Generation

We propose Anomagic, a zero-shot anomaly generation method that produces semantically coherent anomalies without requiring any exemplar anomalies. By unifying both visual and textual cues through a crossmodal prompt encoding scheme, Anomagic leverages rich contextual information to steer an inpainting-based generation pipeline. A subsequent contrastive refinement strategy enforces precise alignment between synthesized anomalies and their masks, thereby bolstering downstream anomaly detection accuracy. To facilitate training, we introduce AnomVerse, a collection of 12,987 anomaly-mask-caption triplets assembled from 13 publicly available datasets, where captions are automatically generated by multimodal large language models using structured visual prompts and template-based textual hints. Extensive experiments demonstrate that Anomagic trained on AnomVerse can synthesize more realistic and varied anomalies than prior methods, yielding superior improvements in downstream anomaly detection. Furthermore, Anomagic can generate anomalies for any normal-category image using user-defined prompts, establishing a versatile foundation model for anomaly generation.